Corrigendum: Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells
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چکیده
منابع مشابه
Modulation of the axonal microtubule cytoskeleton by myelinating Schwann cells.
The Trembler PNS myelin-deficient mutant mouse offers a unique model for the study of axon-glial interactions. Previous work in our laboratory on Trembler mouse sciatic nerve established that myelinating Schwann cells exert a profound effect on the underlying neuronal cytoskeleton. Demyelinated axon segments exhibited decreases in the rate of slow axonal transport, axonal caliber, and neurofila...
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Myelin-associated glycoprotein (MAG) is an integral membrane protein expressed by myelinating glial cells that occurs in two developmentally regulated forms with different carboxyterminal cytoplasmic domains (L-MAG and S-MAG). To investigate the role of MAG in myelination a recombinant retrovirus was used to introduce a MAG cDNA (L-MAG form) into primary Schwann cells in vitro. Stably infected ...
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Terminal Schwann cells (tSCs) are non-myelinating glia that cover the nerve terminal at the neuromuscular junction. They are required for the maintenance of the neuromuscular synapse and are likely to play essential roles in the restoration of synaptic connections after nerve injury. Terminal SCs acquire a reactive phenotype after nerve damage characterized by the extension of cellular processe...
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This chapter will review basic and clinical findings regarding the cardioprotective role of Neuregulin1-ErbB signaling against the cardiotoxicity of doxorubicin, a widely used chemotherapeutic agent. In 2001, The New England Journal of Medicine published the results from clinical trials in breast cancer patients using Trastuzumab, a monoclonal antibody that blocks the ErbB2 receptor. These stud...
متن کاملTransgenic expression of human connexin32 in myelinating Schwann cells prevents demyelination in connexin32-null mice.
Mutations in Gap Junction beta1 (GJB1), the gene encoding the gap junction protein connexin32 (Cx32), cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating neuropathy. We investigated the possibility that the expression of mutant Cx32 in other cells besides myelinating Schwann cells contributes to the development of demyelination. Human Cx32 was expressed in...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2018
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.318477.118